Determining the effects of encapsulated sodium butyrate with varying releasing times in broilers
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Sodium butyrate (Na-B) has been shown to impact growth performance and gut health in chickens raised without antibiotics. In Experiment 1, the feed rate-of-passage of 3-week-old broilers was determined via a computed tomography assay. The results suggested that 30 minutes to 2.5 hour post-ingestion is the appropriate time for the release of encapsulated Na-B aimed at stimulating intestinal epithelial development and improving nutrient digestibility. For those products that focus on hindgut bacterial control, 2.5 to 4 hour would be an optimal range for the releasing time. Experiment 2 evaluated two encapsulated Na-B products with different releasing times over a range of dosages (250, 500, 750, 1000, and 1500 ppm). The 2 h releasing time product at 1000 ppm significantly improved the BW on d 21, and showed the highest villus height in the jejunum when added at 750 ppm. Experiment 3 evaluated three Na-B products with varying releasing times on broiler performance with a Salmonella typhimurium challenge. The 2 h and 3-4 h releasing time Na-B products both showed the potential to improve villus growth and ileal digestible energy (IDE). However, both Experiment 2 and 3 did not show significant effect on Salmonella colonization. In Experiment 4, two releasing time Na-B products were evaluated for a full grow-out period in broilers. Adding 2 h and 3-4 h releasing time Na-B products at 500 and 1000 ppm improved the IDE, but did not show significant effect on growth without an experimental challenge. Experiment 5 evaluated two Na-B products with targeted releasing times on growth and mitigating necrotic enteritis. The 2 h releasing time product at 500 ppm showed significantly higher BW compared to the challenge control on d 21. Both the 2 h and 3-4 h releasing time products showed a mitigation impact on the lesions associated with necrotic enteritis. In conclusion, encapsulated Na-B has the potential to improve growth, IDE, villus development, and showed the ability to mitigate the impact of necrotic enteritis in challenged broilers. The beneficial effects on growth performance and gut health are affected not only by the dosage level, but also by the product’s releasing time.