Photoconjugation and photorelease:
Valencia, Joshua A
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The fast and effective photogeneration of o-naphthoquinone methides (NQM) from a naphthoquinone methide precursor (NQMP) has been well studied for its use in protein labelling and the patterning of surfaces. We have developed a method for using the fast photogeneration of NQM from NQMP derivatives to synthesize an NQMP-photobase derivative. This neutral molecule is capable of releasing a mild organic base under a few minutes of ultraviolet irradiation. Additionally, we have investigated a method of using the fast Diels-Alder reaction of NQM with enamines to conjugate enamines generated in-situ from aldehydes or ketones to a surface.