The genetic basis of impulsive personality traits: a prioritized subset approach
Gray, Joshua Charles
MetadataShow full item record
This study explored the genetic basis of impulsive personality traits, defined as performance on the Barratt Impulsiveness Scale, Version 11 (BIS-11) and the UPPS-P Impulsive Behavior Scale (UPPS-P), using a prioritized subset approach in a sample of 983 healthy young adults of European ancestry. The study used multivariate analysis to assess the relationship between impulsive personality traits and: 1) 21 a priori single nucleotide polymorphisms previously associated with impulsive personality traits; 2) 13,337 high-value addiction (HVA) markers (from the SmokeScreen© array); and 3) ~5M genome-wide loci. This study identified a significant relationship between impulsive personality traits and two previously identified candidate loci (rs6313 and rs6311), both within the 5-HT2a receptor gene (HTR2a). Follow-up analyses suggested that the effects were specific to the BIS-11 Motor and Non-planning subscales. Analyses of the HVA loci and genome-wide loci yielded no statistically significant findings, but suggestive associations were present for loci in BIK, STOX2, ITGB1, and LMNTD1. This study further implicates loci within HTR2a with self-reported impulsive personality traits for future replication and identified suggestive loci from the HVA and genome-wide analyses.