Interactions between genetic background and diet
Norris, Kathleen Marie
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The glutathione (GSH) antioxidant system governs cellular protection against oxidative stress, which is characterized by depletion of GSH and subsequent accumulation of the dimer glutathione disulfide (GSSG). Previous research indicates a negative effect of a high-fat diet on GSH redox status (GSH/GSSG) and a possible protective effect of certain flavonoids such as anthocyanins. Although tissue levels of GSH, GSSG, and GSH/GSSG are also heritable, it is unclear whether genetic background and diet interact to regulate the GSH system. The current work tested the hypothesis that a high-fat diet regulates GSH homeostasis in a manner dependent on genetic background. Additionally, it tested the hypothesis that anthocyanin-induced alterations in GSH homeostasis are genetically determined. Both hypotheses were confirmed, indicating that a high-fat diet and anthocyanin supplementation interact with genetic background to regulate the GSH system and subsequent chronic disease risk.