Blueberry supplementation alters markers of oxidative stress in high fat fed rats
Keirsey, Katherine Iampietro
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Oxidative stress has been implicated as a causal or contributing factor to a number of chronic diseases. Blueberries contain high levels of anthocyanins, which may mitigate oxidative stress and inflammation. Our objective was to determine if blueberry supplementation would decrease oxidative stress and colon inflammation in high fat fed rats. Wistar rats (n= 8/group) were fed low-fat (LF), high-fat (HF) or high-fat with 10% blueberry (HF_BB) diets for 8 wks. Biomarkers of colon inflammation and systemic, liver, and colon oxidative stress were measured. Markers of colon inflammation were not significantly altered by blueberry feeding in high fat fed rats. Some changes were observed in oxidative stress with blueberry feeding, and the direction of change was tissue specific.