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dc.contributor.authorBossie, Hannah Michelle
dc.date.accessioned2017-03-24T04:30:35Z
dc.date.available2017-03-24T04:30:35Z
dc.date.issued2016-08
dc.identifier.otherbossie_hannah_m_201608_ms
dc.identifier.urihttp://purl.galileo.usg.edu/uga_etd/bossie_hannah_m_201608_ms
dc.identifier.urihttp://hdl.handle.net/10724/36627
dc.description.abstractPURPOSE: Evaluate skeletal muscle mitochondrial capacity and muscle-specific endurance using noninvasive methods in persons with Friedreich’s Ataxia (FRDA) and able-bodied controls (AB). METHODS: Participants with FRDA (n=16) and AB controls (n=10) were tested (ages 8-55 yrs). Forearm mitochondrial capacity was measured using the rate of recovery of oxygen consumption after electrical stimulation with near-infrared spectroscopy. Mechanomyography was used to assess muscle-specific endurance after electrical stimulation for 3 minutes at 2Hz, 4Hz, and 6Hz sequentially. RESULTS: There was no difference in mitochondrial capacity (FRDA and AB: 1.8 ± 0.3 1/min). Muscle-specific endurance was significantly impaired by 14% in the FRDA participants in comparison to AB controls (p < 0.001). Correlations show a positive, moderate relationship between these two measurements and a negative, moderate relationship with disease severity in the FRDA group. CONCLUSIONS: Impairments in endurance and relationships between disease severity, endurance and mitochondrial capacity suggest that these measurements can be useful to monitor people with FRDA. The ease of testing and noninvasive nature of these methods also make them appropriate for futures studies.
dc.languageeng
dc.publisheruga
dc.rightspublic
dc.subjectNIRS
dc.subjectFriedreich’s Ataxia
dc.subjectmitochondrial capacity
dc.subjectmechanomyography
dc.titleSkeletal muscle mitochondrial capacity and muscle-specific endurance in persons with Friedreich's ataxia
dc.typeThesis
dc.description.degreeMS
dc.description.departmentKinesiology
dc.description.majorExercise Science
dc.description.advisorKevin McCully
dc.description.committeeKevin McCully
dc.description.committeePatrick J O'Connor
dc.description.committeeEllen Evans


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