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dc.contributor.authorPeng, Duo
dc.date.accessioned2016-11-23T05:30:16Z
dc.date.available2016-11-23T05:30:16Z
dc.date.issued2016-05
dc.identifier.otherpeng_duo_201605_ms
dc.identifier.urihttp://purl.galileo.usg.edu/uga_etd/peng_duo_201605_ms
dc.identifier.urihttp://hdl.handle.net/10724/36301
dc.description.abstractThe genome of the protozoan parasite Trypanosoma cruzi, the causative agent of Chagas disease, encodes a family of genes consisting of 3209 trans-sialidase (TcTS) and TcTS-like genes. Simultaneous expression of many members of the TcTS/TcTS-like family (henceforth TcTS gene family) presents variant peptide antigens to the host immune system. Recombination is a major force in generating and spreading genetic variation in gene families and such a process has been documented in Trypanosoma brucei and Plasmodium to contribute to antigenic variation. To investigate the extent to which recombination creates genetic variation in TcTS gene family, we have developed a computational pipeline capable of analyzing recombination events in the entire TcTS gene family. Using this computational pipeline, we demonstrate that TcTS gene family members are undergoing frequent recombination, generating new variants from the thousands of functional and non-functional gene segments.
dc.languageeng
dc.publisheruga
dc.rightsOn Campus Only Until 2018-05-01
dc.subjecttrans-sialidase
dc.subjectrecombination
dc.subjectgene conversion
dc.subjectT. cruzi
dc.titleFrequent intra-family recombination in the largest repository of antigen variants in the protozoan pathogen Trypanosoma cruzi
dc.typeThesis
dc.description.degreeMS
dc.description.departmentBioinformatics
dc.description.majorBioinformatics
dc.description.advisorRick Tarleton
dc.description.committeeRick Tarleton
dc.description.committeeRobert Sabatini
dc.description.committeeJESSICA C. KISSINGER


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