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dc.contributor.authorMeyer, Dean Vallen
dc.date.accessioned2016-02-25T05:30:26Z
dc.date.available2016-02-25T05:30:26Z
dc.date.issued2015-08
dc.identifier.othermeyer_dean_v_201508_phd
dc.identifier.urihttp://purl.galileo.usg.edu/uga_etd/meyer_dean_v_201508_phd
dc.identifier.urihttp://hdl.handle.net/10724/34465
dc.description.abstractCaenorhabditis elegans is a bacterivorous nematode used as a model organism in biosciences research. Its characteristics make it suitable for toxicological investigations of environmental exposures. It has been used extensively to assess the effects of exposure to metals. Nickel is a ubiquitous metal present in the soil, air, and water, to which all living organisms are exposed daily. In this dissertation, the effects of nickel on C. elegans are examined, with particular emphasis on characterizing cellular detoxification pathways involved in counteracting the effects of high concentrations of nickel. Pathways studied included metallothioneins, divalent metal transporters, a heat shock protein, an ABC transporter, phytochelatin, and coelomocytes. In addition, this dissertation evaluated the differential toxicity of seven soluble nickel salts, and investigated whether nickel caused degeneration of cholinergic and dopaminergic pathways in C. elegans.
dc.languageeng
dc.publisheruga
dc.rightspublic
dc.subjectNickel
dc.subjectCaenorhabditis elegans
dc.subjectdetoxification
dc.titleMolecular mechanisms of action of nickel in the nematode Caenorhabditis elegans
dc.typeDissertation
dc.description.degreePhD
dc.description.departmentEnvironmental Health Science
dc.description.majorToxicology
dc.description.advisorPhillip L. Williams
dc.description.committeePhillip L. Williams
dc.description.committeeJia-Sheng Wang
dc.description.committeeRobert Gogal, Jr.
dc.description.committeeTravis C. Glenn
dc.description.committeeKevin K Dobbin


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