Elucidating driving forces in ovary follicle cell proliferation and egg maturation in Aedes aegypti
Mattee, Melissa Terese
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The yellow fever mosquito Aedes aegypti is responsible for the transmission of yellow fever, Chickungunya and Dengue viruses, filarial worms, and numerous other pathogens that cause disease in humans and animals. Insecticides remain a prominent means of mosquito population control, but the spread of resistance to these necessitates further knowledge of important biological processes that could be potential control targets, such as reproduction. I have found that insulin-like peptides and ovary ecdysteroidogenic hormone stimulate follicle cell proliferation in vitro, and this stimulation is sensitive to insulin and target of rapamycin signaling inhibitors (OSI-906 and Torin 2, respectively). In vivo experiments with these inhibitors had inconsistent effects on survival and little effect on egg maturation.