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dc.contributor.authorChen, Chen
dc.date.accessioned2016-02-09T05:30:25Z
dc.date.available2016-02-09T05:30:25Z
dc.date.issued2015-08
dc.identifier.otherchen_chen_201508_ms
dc.identifier.urihttp://purl.galileo.usg.edu/uga_etd/chen_chen_201508_ms
dc.identifier.urihttp://hdl.handle.net/10724/34159
dc.description.abstractDeltamethrin (DLM) is a pyrethroid pesticide. The objective of this study was to characterize the toxicokinetics (TK) of DLM in rats. Serial blood samples were taken from adult rats following oral/i.v. administration. Serial sacrifice was performed on rats in three age groups. Plasma and tissue samples were analyzed for DLM concentration. The time-course data were analyzed to estimate TK parameters. Absorption of DLM was protracted and incomplete. The vehicle influenced the plasma TK profile. Plasma time-courses of different dosages paralleled one another, with TK generally linear over the evaluated range, typically exhibiting a progressive increase, a plateau, and a slow terminal elimination phase. Age was inversely related to the extent of systemic exposure given the same dosage. Brain concentrations were lower than plasma levels. Plasma and tissue profiles showed inconsistency among the age groups. This indicates age-difference of DLM kinetics, which may be important in risk assessments.
dc.languageeng
dc.publisheruga
dc.rightspublic
dc.subjectAdult Rats
dc.subjectDeltamethrin
dc.subjectGC-MS
dc.subjectI.V. Dosing
dc.subjectJuvenile Rats
dc.subjectOral Dosing
dc.subjectTissue Distribution
dc.subjectToxicokinetics
dc.subjectWeanling Rats
dc.titleToxicokinetics of deltamethrin in rats
dc.title.alternativevehicle, dosage, and age dependency
dc.typeThesis
dc.description.degreeMS
dc.description.departmentPharmaceutical and Biomedical Sciences
dc.description.majorToxicology
dc.description.advisorJames Bruckner
dc.description.committeeJames Bruckner
dc.description.committeeCatherine White
dc.description.committeeRandall Tackett


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