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dc.contributor.authorMahbub, Ridwan Amin
dc.date.accessioned2015-10-29T04:30:20Z
dc.date.available2015-10-29T04:30:20Z
dc.date.issued2015-05
dc.identifier.othermahbub_ridwan_a_201505_ms
dc.identifier.urihttp://purl.galileo.usg.edu/uga_etd/mahbub_ridwan_a_201505_ms
dc.identifier.urihttp://hdl.handle.net/10724/33196
dc.description.abstractNicotine exposure from tobacco smoke and electronic cigarettes has become a major public health problem. As both nicotine and gut microbiome are known to mediate metabolism in the body, it is of interest to know how nicotine exposure can affect the gut microbiome and the serum metabolite profile. Male and female C57BL/6 mice were exposed to 6 mg/L (low dose) and 60 mg/L (high dose) nicotine in drinking water for 13 weeks. High dose had a more different gut microbial profile and more changes to the serum metabolite profile than low dose. 16S rRNA sequencing found nicotine changed gut microbial community structure mainly at the family and genus level, with some gender differences. Gas-chromatography mass spectrometry serum profiling found gender-differences to changes in several metabolites. Our results are the first to exclusively look at the effects of nicotine on the mice gut microbiome and the serum metabolite profile.
dc.languageeng
dc.publisheruga
dc.rightsOn Campus Only Until 2017-05-01
dc.subjectNicotine
dc.subjectEnvironmental Exposure
dc.subjectMetabolomics
dc.subjectGut Microbiome
dc.titleThe effects of nicotine on the gut microbiome and the serum metabolite profile of mice
dc.typeThesis
dc.description.degreeMS
dc.description.departmentEnvironmental Health Science
dc.description.majorEnvironmental Health
dc.description.advisorKun Lu
dc.description.committeeKun Lu
dc.description.committeeMary Alice Smith
dc.description.committeeTravis Glenn


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