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dc.contributor.authorMatiasek, Kaspar
dc.contributor.authorPumarola i Batlle, Martí
dc.contributor.authorRosati, Marco
dc.contributor.authorFernández-Flores, Francisco
dc.contributor.authorFischer, Andrea
dc.contributor.authorWagner, Eva
dc.contributor.authorBerendt, Mette
dc.contributor.authorBhatti, Sofie F M
dc.contributor.authorDe Risio, Luisa
dc.contributor.authorFarquhar, Robyn G
dc.contributor.authorLong, Sam
dc.contributor.authorMuñana, Karen
dc.contributor.authorPatterson, Edward E
dc.contributor.authorPakozdy, Akos
dc.contributor.authorPenderis, Jacques
dc.contributor.authorPlatt, Simon
dc.contributor.authorPodell, Michael
dc.contributor.authorPotschka, Heidrun
dc.contributor.authorRusbridge, Clare
dc.contributor.authorStein, Veronika M
dc.contributor.authorTipold, Andrea
dc.contributor.authorVolk, Holger A
dc.date.accessioned2015-09-24T16:39:12Z
dc.date.available2015-09-24T16:39:12Z
dc.date.issued2015-08-28
dc.identifier.citationBMC Veterinary Research. 2015 Aug 28;11(1):216
dc.identifier.urihttp://dx.doi.org/10.1186/s12917-015-0467-9
dc.identifier.urihttp://hdl.handle.net/10724/32621
dc.description.abstractAbstract Traditionally, histological investigations of the epileptic brain are required to identify epileptogenic brain lesions, to evaluate the impact of seizure activity, to search for mechanisms of drug-resistance and to look for comorbidities. For many instances, however, neuropathological studies fail to add substantial data on patients with complete clinical work-up. This may be due to sparse training in epilepsy pathology and or due to lack of neuropathological guidelines for companion animals. The protocols introduced herein shall facilitate systematic sampling and processing of epileptic brains and therefore increase the efficacy, reliability and reproducibility of morphological studies in animals suffering from seizures. Brain dissection protocols of two neuropathological centres with research focus in epilepsy have been optimised with regards to their diagnostic yield and accuracy, their practicability and their feasibility concerning clinical research requirements. The recommended guidelines allow for easy, standardised and ubiquitous collection of brain regions, relevant for seizure generation. Tissues harvested the prescribed way will increase the diagnostic efficacy and provide reliable material for scientific investigations.
dc.titleInternational veterinary epilepsy task force recommendations for systematic sampling and processing of brains from epileptic dogs and cats
dc.typeJournal Article
dc.date.updated2015-09-22T12:00:50Z
dc.language.rfc3066en
dc.rights.holderMatiasek et al.


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