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dc.contributor.authorSamir, Anthony E
dc.contributor.authorAllegretti, Andrew S
dc.contributor.authorZhu, Qingli
dc.contributor.authorDhyani, Manish
dc.contributor.authorAnvari, Arash
dc.contributor.authorSullivan, Dorothy A
dc.contributor.authorTrottier, Caitlin A
dc.contributor.authorDougherty, Sarah
dc.contributor.authorWilliams, Winfred W
dc.contributor.authorBabitt, Jodie L
dc.contributor.authorWenger, Julia
dc.contributor.authorThadhani, Ravi I
dc.contributor.authorLin, Herbert Y
dc.date.accessioned2015-09-01T18:52:01Z
dc.date.available2015-09-01T18:52:01Z
dc.date.issued2015-07-31
dc.identifier.citationBMC Nephrology. 2015 Jul 31;16(1):119
dc.identifier.urihttp://dx.doi.org/10.1186/s12882-015-0120-7
dc.identifier.urihttp://hdl.handle.net/10724/32094
dc.description.abstractAbstract Background There currently is a need for a non-invasive measure of renal fibrosis. We aim to explore whether shear wave elastography (SWE)-derived estimates of tissue stiffness may serve as a non-invasive biomarker that can distinguish normal and abnormal renal parenchymal tissue. Methods Participants with CKD (by estimated GFR) and healthy volunteers underwent SWE. Renal elasticity was estimated as Young’s modulus (YM) in kilopascals (kPa). Univariate Wilcoxon rank-sum tests were used. Results Twenty-five participants with CKD (median GFR 38 mL/min; quartile 1, quartile 3 28, 42) and 20 healthy controls without CKD underwent SWE performed by a single radiologist. CKD was associated with increased median YM (9.40 [5.55, 22.35] vs. 4.40 [3.68, 5.70] kPa; p = 0.002) and higher median intra-subject inter-measurement estimated YM’s variability (4.27 [2.89, 9.90] vs. 1.51 [1.21, 2.05] kPa; p < 0.001). Conclusions SWE-derived estimates of renal stiffness and intra-subject estimated stiffness variability are higher in patients with CKD than in healthy controls. Renal fibrosis is a plausible explanation for the observed difference in YM. Further studies are required to determine the relationship between YM, estimated renal stiffness, and renal fibrosis severity.
dc.titleShear wave elastography in chronic kidney disease: a pilot experience in native kidneys
dc.typeJournal Article
dc.date.updated2015-07-31T03:53:26Z
dc.language.rfc3066en
dc.rights.holderSamir et al.


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