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    A novel cytosporone 3-Heptyl-4,6-dihydroxy-3H-isobenzofuran-1-one: synthesis; toxicological, apoptotic and immunomodulatory properties; and potentiation of mutagenic damage

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    Date
    2015-07-31
    Author
    Oliveira, Rodrigo J
    Navarro, Stephanie D
    de Lima, Dênis P
    Meza, Alisson
    Pesarini, João R
    da Silva Gomes, Roberto
    Karaziack, Caroline B
    de Oliveira Mauro, Mariana
    Cunha-Laura, Andréa L
    Monreal, Antônio C D
    Romão, Wanderson
    Júnior, Valdemar L
    Beatriz, Adilson
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    Abstract
    Abstract Background A large number of studies are attempting to identify alternative products from natural sources or synthesized compounds that effectively interact with cancer cells without causing adverse effects on healthy cells. Resorcinolic lipids are a class of bioactive compounds that possess anticancer activity and are able to interact with the lipid bilayer. Therefore, the objective of this study was to synthesize a novel resorcinolic lipid and test its biological proprieties. Methods We aimed to synthesize a novel resorcinolic lipid belonging to the class of cytosporones, AMS049 (3-Heptyl-4,6-dihydroxy-3H-isobenzofuran-1-one) and to evaluate the toxicity of two concentrations of this lipid (7.5 and 10 mg/kg) by determining its genotoxic, mutagenic, immunomodulatory, and apoptotic effects, as well as any biochemical and histopathological alterations in mice treated with cyclophosphamide. The results were analyzed by ANOVA followed by the Tukey test A . level of significance of p < 0.05 was adopted. Results The new cytosporone AMS049 was synthesized in only three steps and in satisfactory yields. The results indicate that the compound is neither genotoxic nor mutagenic and does not alter biochemical parameters. The histological alterations observed in the liver and kidneys did not compromise the function of these organs. Histology of the spleen suggested immunomodulation, although no changes were observed in splenic phagocytosis or differential blood cell count. The results also show that AMS049 potentiates the mutagenic effect of the chemotherapy drug cyclophosphamide and that the combination induces apoptosis. Conclusion These facts indicate a potential therapeutic application of this novel cytosporone as an important chemotherapeutic adjuvant.
    URI
    http://dx.doi.org/10.1186/s12885-015-1532-2
    http://hdl.handle.net/10724/32086
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