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dc.contributor.authorInoue, Ritsurou
dc.contributor.authorAoki, Mikiko
dc.contributor.authorMatsumoto, Yoshihisa
dc.contributor.authorHaraoka, Seiji
dc.contributor.authorKazekawa, Kiyoshi
dc.contributor.authorNabeshima, Kazuki
dc.date.accessioned2015-09-01T18:43:06Z
dc.date.available2015-09-01T18:43:06Z
dc.date.issued2015-07-31
dc.identifier.citationWorld Journal of Surgical Oncology. 2015 Jul 31;13(1):229
dc.identifier.urihttp://dx.doi.org/10.1186/s12957-015-0655-x
dc.identifier.urihttp://hdl.handle.net/10724/32055
dc.description.abstractAbstract Reported herein is a 25-year-old woman who was treated for a large and highly atypical prolactin-producing pituitary adenoma. On presentation, she exhibited right hemiparesis and left-sided visual loss, associated with amenorrhea. A massive (>5 cm) intra- and suprasellar lesion was seen on imaging, and her serum prolactin level was 4408 ng/ml. The patient received dopamine agonist treatment preoperatively for 4 weeks. To resect the tumor, a two-stage excision was required. Histologically, the specimen was composed of polygonal or spindle cells showing marked nuclear pleomorphism and/or multinucleation. Fibrosis was also focally conspicuous. Differential diagnoses included pituitary adenoma, pituitary carcinoma, pituicytoma, paraganglioma, spindle cell oncocytoma, and meningioma. Immunohistochemically, the tumor cells were positive for prolactin, chromogranin-A, and synaptophysin, but were negative for glial fibrillary acidic protein, S-100 protein, epithelial membrane antigen, and vimentin. No apparent cerebrospinal or systemic metastases are found. Ultimately, prolactin-producing pituitary adenoma was diagnosed. Our case highlights the difficulty in definitively diagnosing an unusual prolactin-producing adenoma based on histopathology alone and the importance of referring to clinical information and immunohistochemical findings when deriving the diagnosis.
dc.titleProlactin-producing pituitary adenoma with atypical spindle cell morphology: a case report
dc.typeJournal Article
dc.date.updated2015-07-31T03:47:06Z
dc.language.rfc3066en
dc.rights.holderInoue et al.


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