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dc.contributor.authorTrerotola, Marco
dc.contributor.authorRelli, Valeria
dc.contributor.authorSimeone, Pasquale
dc.contributor.authorAlberti, Saverio
dc.date.accessioned2015-09-01T18:15:08Z
dc.date.available2015-09-01T18:15:08Z
dc.date.issued2015-07-28
dc.identifier.citationHuman Genomics. 2015 Jul 28;9(1):17
dc.identifier.urihttp://dx.doi.org/10.1186/s40246-015-0041-3
dc.identifier.urihttp://hdl.handle.net/10724/31973
dc.description.abstractAbstract Genome-wide association studies of complex physiological traits and diseases consistently found that associated genetic factors, such as allelic polymorphisms or DNA mutations, only explained a minority of the expected heritable fraction. This discrepancy is known as “missing heritability”, and its underlying factors and molecular mechanisms are not established. Epigenetic programs may account for a significant fraction of the “missing heritability.” Epigenetic modifications, such as DNA methylation and chromatin assembly states, reflect the high plasticity of the genome and contribute to stably alter gene expression without modifying genomic DNA sequences. Consistent components of complex traits, such as those linked to human stature/height, fertility, and food metabolism or to hereditary defects, have been shown to respond to environmental or nutritional condition and to be epigenetically inherited. The knowledge acquired from epigenetic genome reprogramming during development, stem cell differentiation/de-differentiation, and model organisms is today shedding light on the mechanisms of (a) mitotic inheritance of epigenetic traits from cell to cell, (b) meiotic epigenetic inheritance from generation to generation, and (c) true transgenerational inheritance. Such mechanisms have been shown to include incomplete erasure of DNA methylation, parental effects, transmission of distinct RNA types (mRNA, non-coding RNA, miRNA, siRNA, piRNA), and persistence of subsets of histone marks.
dc.titleEpigenetic inheritance and the missing heritability
dc.typeJournal Article
dc.date.updated2015-07-29T19:10:19Z
dc.language.rfc3066en
dc.rights.holderTrerotola et al.


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