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dc.contributor.authorDhakal, Bishnu P
dc.contributor.authorTribble, Curtis G
dc.contributor.authorBergin, James D
dc.contributor.authorWinfrey, Sean
dc.contributor.authorCarter, William H
dc.date.accessioned2015-09-01T18:02:20Z
dc.date.available2015-09-01T18:02:20Z
dc.date.issued2015-07-30
dc.identifier.citationJournal of Cardiothoracic Surgery. 2015 Jul 30;10(1):105
dc.identifier.urihttp://dx.doi.org/10.1186/s13019-015-0309-7
dc.identifier.urihttp://hdl.handle.net/10724/31930
dc.description.abstractAbstract Background Candida prosthetic endocarditis (CPE) is an uncommon disease involving less than 1 % of infective endocarditis patients and associated with high recurrence rate. Immunosuppresion, intravenous drug abuse, cardiac surgery and indwelling foreign bodies are the major risk factors for CPE. There are very few reported cases of CPE where more than one surgery was performed and there has generally been limited follow up on these cases. Case presentation We report a case of a 35 year old woman who had mitral valve annuloplasty complicated by recurrent episodes of CPE leading to multiple mitral valve replacements (MVR). She underwent MVR surgeries a total of four times over an eighteen year period and had good functionality during most of this time while being on antifungal suppressive treatment. This is a unique case in terms of numbers of surgeries performed, the length of the follow up and the involvement of three different Candida species. Conclusion Current guidelines for the treatment of candida endocarditis recommend surgical treatment followed by long term antifungal therapy although the cure rate by all treatments is low. However we feel that based on this one case it is reasonable to consider multiple redo valve replacement surgeries in conjunction with antifungal treatment for selected patients stable enough to tolerate the surgery.
dc.titleRecurrent candida prosthetic endocarditis over fifteen years managed with medical therapy and four valvular surgeries: a case report and review of literature
dc.typeJournal Article
dc.date.updated2015-07-29T19:04:25Z
dc.language.rfc3066en
dc.rights.holderDhakal et al.


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