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dc.contributor.authorTakahashi, Hiroshi
dc.contributor.authorIkeda, Kazuhiko
dc.contributor.authorOgawa, Kazuei
dc.contributor.authorSaito, Syunnichi
dc.contributor.authorNgoma, Alain M
dc.contributor.authorMashimo, Yumiko
dc.contributor.authorUeda, Koki
dc.contributor.authorFurukawa, Miki
dc.contributor.authorShichishima-Nakamura, Akiko
dc.contributor.authorOhkawara, Hiroshi
dc.contributor.authorNollet, Kenneth E
dc.contributor.authorOhto, Hitoshi
dc.contributor.authorTakeishi, Yasuchika
dc.date.accessioned2015-09-01T17:26:15Z
dc.date.available2015-09-01T17:26:15Z
dc.date.issued2015-07-26
dc.identifier.citationBiological Research. 2015 Jul 26;48(1):41
dc.identifier.urihttp://dx.doi.org/10.1186/s40659-015-0033-8
dc.identifier.urihttp://hdl.handle.net/10724/31793
dc.description.abstractAbstract Background CD4+CD25highFOXP3+ regulatory T (Treg) cells, which include thymus-derived and peripherally induced cells, play a central role in immune regulation, and are therefore crucial to prevent graft-versus-host disease (GVHD). The increasing use of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for elderly patients with thymus regression, and our case of allo-HSCT shortly after total thymectomy, raised questions about the activity of thymus-derived Treg cells and peripherally induced Treg cells, which are otherwise indistinguishable. Results We found that despite pre-transplant thymectomy or older age, both naïve and effector Treg cells, as well as naïve and effector conventional T cells, proliferated in allo-HSCT recipients. Higher proportions of total Treg cells 1 month post allo-HSCT, and naïve Treg cells 1 year post allo-HSCT, appeared in patients achieving complete chimera without developing significant chronic GVHD, including our thymectomized patient, compared with patients who developed chronic GVHD. Conclusions Treg cells that modulate human allogeneic immunity may arise peripherally as well as in the thymus of allo-HSCT recipients.
dc.titleCD4+ T cells in aged or thymectomized recipients of allogeneic stem cell transplantations
dc.typeJournal Article
dc.date.updated2015-07-29T18:30:24Z
dc.language.rfc3066en
dc.rights.holderTakahashi et al.


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