Show simple item record

dc.contributor.authorBroekhuizen, Karen
dc.contributor.authorvan Wier, Marieke F
dc.contributor.authorKoppes, Lando L J
dc.contributor.authorBrug, Johannes
dc.contributor.authorvan Mechelen, Willem
dc.contributor.authorBosmans, Judith E
dc.contributor.authorvan Poppel, Mireille N M
dc.date.accessioned2015-09-01T17:10:31Z
dc.date.available2015-09-01T17:10:31Z
dc.date.issued2015-07-29
dc.identifier.citationBMC Research Notes. 2015 Jul 29;8(1):317
dc.identifier.urihttp://dx.doi.org/10.1186/s13104-015-1282-x
dc.identifier.urihttp://hdl.handle.net/10724/31743
dc.description.abstractAbstract Background Cost-effectiveness analyses provide insight in the use of lifestyle interventions. To evaluate the cost-effectiveness of a lifestyle intervention compared to usual care in people with Familial Hypercholesterolemia, 340 people with FH were randomized to the intervention or control group. LDL cholesterol, quality of life and costs were measured at 0 and 12 months. Cost-effectiveness analyses were performed from a healthcare perspective using bootstrapping techniques. Results Non-significant decreases in LDL cholesterol and quality of life were found. The mean between-group difference in costs was €−237 (95% CI −1,386 to 130). The incremental cost-effectiveness ratios were 1,729 per 1 mmol/l LDL cholesterol and 145,899 per QALY gained. Assumed that the small non-significant decrease in LDL cholesterol is attributed to the intervention, the probability of cost-effectiveness of the intervention compared to usual care was 91% per 1 mmol/l LDL cholesterol reduction and 75% per QALY gained at a ceiling ratio of €20,000. Conclusions The intervention is not cost-effective. Trial registration: NTR1899, date 07-07-2009.
dc.titleAn economic evaluation alongside a randomized controlled trial evaluating an individually tailored lifestyle intervention compared with usual care in people with Familial Hypercholesterolemia
dc.typeJournal Article
dc.date.updated2015-07-29T18:23:07Z
dc.language.rfc3066en
dc.rights.holderBroekhuizen et al.


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record