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dc.contributor.authorMarinho, Márcia
dc.contributor.authorTáparo, Cilene V
dc.contributor.authorOliveira-Júnior, Itamar S
dc.contributor.authorPerri, Silvia H V
dc.contributor.authorCardoso, Tereza C
dc.date.accessioned2015-09-01T17:07:27Z
dc.date.available2015-09-01T17:07:27Z
dc.date.issued2015-07-28
dc.identifier.citationJournal of Venomous Animals and Toxins including Tropical Diseases. 2015 Jul 28;21(1):22
dc.identifier.urihttp://dx.doi.org/10.1186/s40409-015-0022-y
dc.identifier.urihttp://hdl.handle.net/10724/31734
dc.description.abstractAbstract Background This investigation aimed to evaluate the occurrence of some apoptotic features induced by Leptospira interrogans serovar Icterohaemorrhagiae infection in young BALB/c mice during 2, 4, 7, 10, 14 and 21 days post-infection (dpi). Methods The animals were euthanized and lung, liver and kidneys were harvested to histopathology analysis and immunohistochemistry to caspase-3 antigen detection was performed. Results Chromatin condensation in kidney and liver tissues, but not in lung tissue, was observed. Caspase-3 reactive cells, mainly characterized as renal epithelial cells, were detected in the days 14 and 21 at high levels when compared to days 2, 4 and 7 (p = 0.025; p < 0.05). Lung sections revealed caspase-3 labeled alveolar cells in 10 and 14 days post-infection was higher than observed at 7 days (p = 0.0497; p < 0.05). Liver sections demonstrated reactive cells at a highest level at 14 and 21 days post-infection when comparison to 2, 4, 7 and 10 days (p = 0.0069; p < 0.05). Conclusions Our results suggest that infection of L. interrogans induce in kidney, liver and lung an activation of apoptosis mediated by caspase-3 dependent pathway in later phases of infectious process.
dc.titleTissue apoptosis in mice infected with Leptospira interrogans serovar Icterohaemorrhagiae
dc.typeJournal Article
dc.date.updated2015-07-29T18:21:10Z
dc.language.rfc3066en
dc.rights.holderMarinho et al.


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