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dc.contributor.authorLi, Gang
dc.contributor.authorLu, Wei-hua
dc.contributor.authorWu, Xiao-wei
dc.contributor.authorCheng, Jian
dc.contributor.authorAi, Rong
dc.contributor.authorZhou, Zi-hua
dc.contributor.authorTang, Zhong-zhi
dc.date.accessioned2015-09-01T16:45:50Z
dc.date.available2015-09-01T16:45:50Z
dc.date.issued2015-07-30
dc.identifier.citationBMC Cardiovascular Disorders. 2015 Jul 30;15(1):79
dc.identifier.urihttp://dx.doi.org/10.1186/s12872-015-0073-6
dc.identifier.urihttp://hdl.handle.net/10724/31657
dc.description.abstractAbstract Background Hypoxia-inducible factor 1 (HIF-1) is a critical regulator for cellular oxygen balance. Myocardial hypoxia can induce the increased expression of HIF-1α. Our goals were to evaluate the value of HIF-1α in predicting death of patients with acute decompensated heart failure (ADHF) and describe the in vivo relationship between serum HIF-1α and N-terminal–pro-brain natriuretic peptide (NT-proBNP) levels. Method We included 296 patients who were consecutively admitted to the emergency department for ADHF. The primary end point was in-hospital death. The patients were categorized as HFrEF (patients with reduced systolic function) and HFpEF (patients with preserved systolic function) groups. Results In our patients, the median admission HIF-1α level was 2.95 ± 0.85 ng/ml. The HIF-1α level was elevated significantly in HFrEF patients and deceased patients compared with HFpEF patients and patients who survived. The HIF-1α level was positively correlated with NT-proBNP and cardiac troponin T levels, and negatively correlated with left ventricular ejection fraction and systolic blood pressure. Kaplan–Meier curves revealed a significant increase in in-hospital mortality in ADHF patients with higher HIF-1α levels. Multivariable Cox regression analysis showed that HIF-1α levels were not correlated with the short-term prognosis of ADHF patients. Conclusions This is the first study to evaluate the circulating levels of HIF-1α in ADHF patients. Serum HIF-1α levels may reflect a serious state in patients with ADHF. Due to the limitations of the study, serum HIF-1α levels were not correlated with the in-hospital mortality based on regression analysis. Further studies are needed to demonstrate the diagnostic and/or prognostic role of HIF-1α as a risk biomarker in patients with ADHF.
dc.titleAdmission hypoxia-inducible factor 1α levels and in-hospital mortality in patients with acute decompensated heart failure
dc.typeJournal Article
dc.date.updated2015-07-29T18:06:54Z
dc.language.rfc3066en
dc.rights.holderLi et al.


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