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dc.contributor.authorChoi, Jay C
dc.contributor.authorLee, Ji S
dc.contributor.authorPark, Tai H
dc.contributor.authorCho, Yong-Jin
dc.contributor.authorPark, Jong-Moo
dc.contributor.authorKang, Kyusik
dc.contributor.authorLee, Kyung B
dc.contributor.authorLee, Soo-Joo
dc.contributor.authorKo, Youngchai
dc.contributor.authorLee, Jun
dc.contributor.authorKim, Joon-Tae
dc.contributor.authorYu, Kyung-Ho
dc.contributor.authorLee, Byung-Chul
dc.contributor.authorCha, Jae-Kwan
dc.contributor.authorKim, Dae-Hyun
dc.contributor.authorLee, Juneyoung
dc.contributor.authorKim, Dong-Eog
dc.contributor.authorJang, Myung S
dc.contributor.authorKim, Beom J
dc.contributor.authorHan, Moon-Ku
dc.contributor.authorBae, Hee-Joon
dc.contributor.authorHong, Keun-Sik
dc.date.accessioned2015-08-31T13:50:39Z
dc.date.available2015-08-31T13:50:39Z
dc.date.issued2015-07-30
dc.identifier.citationBMC Neurology. 2015 Jul 30;15(1):120
dc.identifier.urihttp://dx.doi.org/10.1186/s12883-015-0376-3
dc.identifier.urihttp://hdl.handle.net/10724/31613
dc.description.abstractAbstract Background Experimental studies suggest that pre-stroke statin treatment has a dual effect of neuroprotection during ischemia and neurorestoration after ischemic injury. The aim of this study was to evaluate the effect of pre-stroke statin use on initial stroke severity and early clinical outcome. Methods We used a prospective database enrolling patients with acute ischemic stroke from 12 hospitals in Korea between April 2008 and January 2012. Primary endpoint was the initial stroke severity as measured by the National Institutes of Health Stroke Scale (NIHSS) score. Secondary endpoints were good outcome (modified Rankin Scale [mRS], 0–2) and overall mRS distribution at discharge. Multivariable regression model and propensity score (PS) matching were used for statistical analyses. Results Among the 8340 patients included in this study, 964 patients (11.6 %) were pre-stroke statin users. The initial NIHSS score (mean [95 % CI]) was lower among pre-stroke statin users vs. non-users in multivariable analysis (5.7 [5.2–6.3] versus 6.4 [5.9–6.9], p = 0.002) and PS analysis (5.2 [4.7–5.7] versus 5.7 [5.4–6.0], p = 0.043). Pre-stroke statin use was associated with increased achievement of mRS 0–2 outcome (multivariable analysis: OR [95 % CI], 1.55 [1.25–1.92], p < 0.001; PS matching: OR [95 % CI], 1.47 [1.16-1.88]; p = 0.002) and favorable shift on the overall mRS distribution (multivariable analysis: OR [95 % CI], 1.29 [1.12-1.51], p = 0.001; PS matching: OR [95 % CI], 1.31 [1.11-1.54]; p = 0.001). Conclusions Pre-stroke statin use was independently associated with lesser stroke severity at presentation and better early functional recovery in patients with acute ischemic stroke.
dc.titleEffect of pre-stroke statin use on stroke severity and early functional recovery: a retrospective cohort study
dc.typeJournal Article
dc.date.updated2015-07-29T17:57:45Z
dc.language.rfc3066en
dc.rights.holderChoi et al.


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