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dc.contributor.authorChoi, Joshua Heejae
dc.date.accessioned2015-06-26T04:30:12Z
dc.date.available2015-06-26T04:30:12Z
dc.date.issued2014-12
dc.identifier.otherchoi_joshua_h_201412_ms
dc.identifier.urihttp://purl.galileo.usg.edu/uga_etd/choi_joshua_h_201412_ms
dc.identifier.urihttp://hdl.handle.net/10724/31401
dc.description.abstractMany conventional therapies are used to treat various cancers. However, because of multiple problems that include low efficacy and safety issues, different strategies to treat cancer are necessary. One strategy is combination therapy. Combining drugs or other adjuvants has a synergistic effect in cancer treatments. Combination therapy permits multiple targeting through the same or different signaling pathways to overcome the limitations. Moreover, the use of nanotechnology in combination therapy permits even greater increases in efficacy. The U.S. Food and Drug Administration (FDA) has approved biodegradable polymers such as poly (D,L-lactide-co-glycolide) (PLGA) and poly (ethylene glycol) (PEG) that can be surface modified with targeting moiety for active targeting strategy. PLGA-b-PEG is used for formation of biodegradable polymeric nanoparticles for delivery of payloads. In this thesis, I report on several strategies of combination therapy using polymeric nanoparticles.
dc.languageeng
dc.publisheruga
dc.rightsOn Campus Only Until 2016-12-01
dc.subjectcancer
dc.subjectcombination therapy
dc.subjectbiodegradable polymeric nanoparticles
dc.subjectimmunotherapy
dc.subjectchemotherapy
dc.subjectinflammation
dc.titleBiodegradable polymeric nanoparticles for cancer combination therapy
dc.typeThesis
dc.description.degreeMS
dc.description.departmentChemistry
dc.description.majorChemistry
dc.description.advisorShanta Dhar
dc.description.committeeShanta Dhar
dc.description.committeeRobert Phillips
dc.description.committeeDonald Harn


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