Formulation and rheological characterization of chitosan films
Ahmed, Hishameldin Omer
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The study aims at developing a chitosan film bandage with physical attributes equivalent or better than the predicate Bandage and to further optimize the bandage quality by controlling rheological and viscometric properties of ingredients. Chitosan is a natural polysaccharide that has proven cost effective and the second most abundant natural polymer, it has favorable wound healing properties, biodegradable and biocompatible, the degradation of chitosan results in glucosamine which is endogenic and causes no adverse effects in the body. Chitosan from three grades of molecular weights, 150, 750 and 1190 were formulated using acetic and lactic acids, iodine iodide was added to the film, chitosan gels and films were tested for viscosity, water evaporation for up to three hours at 60 º C, water loss was investigated for periods of 15 minutes at 105 º C, film strength and resistance to breakage were also evaluated. Chitosan can be formulated into gel formulas that can be optimized with understanding and controlling rheological and viscometric properties of ingredients. Chitosan can be cast into films that are stable at elevated temperature and are strong to resist breakage and absorb liquids while maintaining its physical form. To evaluate chitsoan-metal ion complexation by using viscometric methodology. Chitosan solutions from two grades (100 KDA and 500 KDA) were prepared in lactic acid. Complexes of chitosan with magnesium, zinc and ferrous salts (chloride and sulfate) were studied. The polymer to salts ratios were 4:1, 2:1, 1:1, and 1:2. Rheological properties of the mixtures were measured with a Brookfield rheometer, fitted with an SC-52 spindle, at 22 + 2o C. Viscosity increased with the increase in the chitosan molecular weight, and with few exceptions, with the polymer metal ratio. Flow properties were studied by fitting the data to the rheological mathematical models of Bingham, Casson, NCA/Casson and the Power Law, the power law flow indices were less than 1 for the control samples as well as the six salts mixtures which indicates a pseudo plastic behavior for the chitosan complexes regardless of the complexing agent.