Common brain landmarks reflecting consistent structural and functional archetecture
MetadataShow full item record
An unrelenting human quest regarding the brain science is: what is the intrinsic relationship between the brain’s structural and functional architectures, which partly defines what we are and who we are. Recent studies suggest that each brain’s cytoarchitectonic region has a unique set of extrinsic inputs and outputs, named as “connectional fingerprint”, which largely determines the functions that each brain area performs. However, their explicit connections are largely unknown. For example, in what extent they are inclined to be coherent with each other and otherwise they will intend to show more heterogeneity? In this dissertation, based on my previously proposed brain structural atlas which represents the most consistent structural connectome across different populations, I developed a novel group-wise optimization framework to computationally model the functional homogeneity behind them. The optimization procedure is conducted under the joint structural and functional regulations and therefore the achieved common brain landmarks reflect the consistency of brain structure and function simultaneously.