Show simple item record

dc.contributor.authorYang, Mary Q
dc.contributor.authorYoshigoe, Kenji
dc.contributor.authorYang, William
dc.contributor.authorTong, Weida
dc.contributor.authorQin, Xiang
dc.contributor.authorDunker, A K
dc.contributor.authorChen, Zhongxue
dc.contributor.authorArbania, Hamid R
dc.contributor.authorLiu, Jun S
dc.contributor.authorNiemierko, Andrzej
dc.contributor.authorYang, Jack Y
dc.date.accessioned2015-01-05T19:49:51Z
dc.date.available2015-01-05T19:49:51Z
dc.date.issued2014-12-16
dc.identifier.citationBMC Genomics. 2014 Dec 16;15(Suppl 11):I1
dc.identifier.urihttp://dx.doi.org/10.1186/1471-2164-15-S11-I1
dc.identifier.urihttp://hdl.handle.net/10724/30875
dc.description.abstractAbstract Synergistically integrating multi-layer genomic data at systems level not only can lead to deeper insights into the molecular mechanisms related to disease initiation and progression, but also can guide pathway-based biomarker and drug target identification. With the advent of high-throughput next-generation sequencing technologies, sequencing both DNA and RNA has generated multi-layer genomic data that can provide DNA polymorphism, non-coding RNA, messenger RNA, gene expression, isoform and alternative splicing information. Systems biology on the other hand studies complex biological systems, particularly systematic study of complex molecular interactions within specific cells or organisms. Genomics and molecular systems biology can be merged into the study of genomic profiles and implicated biological functions at cellular or organism level. The prospectively emerging field can be referred to as systems genomics or genomic systems biology. The Mid-South Bioinformatics Centre (MBC) and Joint Bioinformatics Ph.D. Program of University of Arkansas at Little Rock and University of Arkansas for Medical Sciences are particularly interested in promoting education and research advancement in this prospectively emerging field. Based on past investigations and research outcomes, MBC is further utilizing differential gene and isoform/exon expression from RNA-seq and co-regulation from the ChiP-seq specific for different phenotypes in combination with protein-protein interactions, and protein-DNA interactions to construct high-level gene networks for an integrative genome-phoneme investigation at systems biology level.
dc.titleThe emerging genomics and systems biology research lead to systems genomics studies
dc.typeJournal Article
dc.date.updated2014-12-18T11:24:59Z
dc.description.versionPeer Reviewed
dc.language.rfc3066en
dc.rights.holderMary Qu Yang et al.; licensee BioMed Central Ltd.


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record