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dc.contributor.authorSouthern, William Michael
dc.date.accessioned2014-11-04T05:30:26Z
dc.date.available2014-11-04T05:30:26Z
dc.date.issued2014-05
dc.identifier.othersouthern_william_m_201405_ms
dc.identifier.urihttp://purl.galileo.usg.edu/uga_etd/southern_william_m_201405_ms
dc.identifier.urihttp://hdl.handle.net/10724/30638
dc.description.abstractThe purpose of this study was to measure muscle oxidative capacity in people with and without heart failure (HF) using near-infrared spectroscopy (NIRS). Participants (aged 45-70 years old) with HF (n = 16) were compared with age-matched controls without HF (n = 20). A subset of participants (HF: n = 7, controls: n = 5) performed 4 weeks of wrist-flexor exercise training. Oxidative capacity was significantly lower in the HF group in both dominant (1.31 ± 0.30 min-1 vs. 1.61 ± 0.24 min-1, p < 0.002) and non-dominant arms (1.29 ± 0.24 min-1 vs. 1.47 ± 0.25 min-1, p < 0.039). After training, the control group exhibited a 51% increase in oxidative capacity, whereas the HF group failed to improve. The reductions in oxidative capacity seen with HF may result from impaired cardiac function or complications of standard pharmacotherapy.
dc.languageeng
dc.publisheruga
dc.rightspublic
dc.subjectOxidative metabolism
dc.subjectendurance training
dc.subjectnear infrared spectroscopy
dc.subjectheart failure
dc.titleReduced skeletal muscle oxidative capacity and impaired training adaptations in people with heart failure
dc.typeThesis
dc.description.degreeMS
dc.description.departmentKinesiology
dc.description.majorKinesiology
dc.description.advisorKevin McCully
dc.description.committeeKevin McCully
dc.description.committeeKent Nilsson
dc.description.committeeJonathan Murrow
dc.description.committeeEllen Evans


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