Reduced skeletal muscle oxidative capacity and impaired training adaptations in people with heart failure
Southern, William Michael
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The purpose of this study was to measure muscle oxidative capacity in people with and without heart failure (HF) using near-infrared spectroscopy (NIRS). Participants (aged 45-70 years old) with HF (n = 16) were compared with age-matched controls without HF (n = 20). A subset of participants (HF: n = 7, controls: n = 5) performed 4 weeks of wrist-flexor exercise training. Oxidative capacity was significantly lower in the HF group in both dominant (1.31 ± 0.30 min-1 vs. 1.61 ± 0.24 min-1, p < 0.002) and non-dominant arms (1.29 ± 0.24 min-1 vs. 1.47 ± 0.25 min-1, p < 0.039). After training, the control group exhibited a 51% increase in oxidative capacity, whereas the HF group failed to improve. The reductions in oxidative capacity seen with HF may result from impaired cardiac function or complications of standard pharmacotherapy.