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dc.contributor.authorMcLain, Duncan
dc.date.accessioned2014-10-09T04:30:23Z
dc.date.available2014-10-09T04:30:23Z
dc.date.issued2014-05
dc.identifier.othermclain_duncan_201405_phd
dc.identifier.urihttp://purl.galileo.usg.edu/uga_etd/mclain_duncan_201405_phd
dc.identifier.urihttp://hdl.handle.net/10724/30544
dc.description.abstractSpatio-temporal release of biologically relevant small molecules provides exquisite control over the activation of receptors and signaling pathways. This can be accomplished via a photochemical reaction that releases the desired small molecule in response to irradiation of light. A series of small molecules (serotonin, capsaicin, VNA, octopamine, tyrosine, dopamine, epinephrine, and norepinephrine) that contain either a phenol or catechol moiety were caged using either BHQ or CyHQ. In all cases the CyHQ caged compounds proved sensitive toward 1PE and 2PE processes with quantum efficiencies of 0.2 – 0.4 upon irradiation at 365 nm and two photon cross sections of 0.15 – 0.31 GM when irradiated at 740 nm. All but two compounds, BHQ-dopamine and BHQ-estradiol were found to be sensitive to both 1PE and 2PE with quantum efficiencies of 0.30 – 0.40 and two photon cross sections of 0.40 – 0.60 GM. CyHQ-epinephrine and CyHQ-norepinephrine possessed a novel photodegradation pathway that was analyzed through radical trapping experiments and product studies
dc.languageeng
dc.publisheruga
dc.rightspublic
dc.subjectCaged compounds
dc.subjecttwo photon excitation
dc.subjectdopamine
dc.subjectneurotransmitters
dc.subjectcatechols
dc.subjectphenols.
dc.titleThe synthesis and characterization of a variety of biologically relevant caged phenols and catechols
dc.typeDissertation
dc.description.degreePhD
dc.description.departmentChemistry
dc.description.majorChemistry
dc.description.advisorTimothy Dore
dc.description.committeeTimothy Dore
dc.description.committeeRobert S Phillips
dc.description.committeeGeorge Majetich


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