Development of Dynamic Intestinal Model (DIM) for digestion kinetics studies
Wright, Nathaniel David
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The human small intestine is a highly specialized organ for the digestion of food and absorption of nutrients. A dynamic Intestinal Model (DIM) was developed in this study with accurate simulation of segmentation contraction. The DIM was verified with pressure test as well as glucose absorption test to measure permeability. These results showed good correlation between results observed in DIM and from in vivo studies done by other researchers. Methylene blue was used to study intestinal digestion kinetics in DIM as related to factors including flow rate of digesta, temperature, viscosity, orientation and segmentation characteristics. Bread digestion was also carried out to study glucose release comparing DIM and commonly used method using shaking water bath to mix digesta. Results showed that a higher amount of glucose was generated in DIM and bile has a strong inhibitory effect in starch digestion.