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dc.contributor.authorSamad, Abdul
dc.date.accessioned2014-03-27T04:30:42Z
dc.date.available2014-03-27T04:30:42Z
dc.date.issued2013-08
dc.identifier.othersamad_abdul_201308_phd
dc.identifier.urihttp://purl.galileo.usg.edu/uga_etd/samad_abdul_201308_phd
dc.identifier.urihttp://hdl.handle.net/10724/29647
dc.description.abstractMany intractable problems on graphs are polynomial time solvable when the graphs have bounded treewidth. An important class of the graphs with bounded treewidth is called k-trees, which are formed by starting with a k-clique and then repeatedly adding vertices in such a way that each added vertex has exactly k neighbors that form a new clique. Finding spanning k-trees has applications in networks where it was first studied in networks, and was later shown to be NP-Complete even for k =2. Biomolecule (protein, RNA) structure prediction is a grand challenge which leads to many computation methods in bioinformatics. We model the biomolecular structure prediction problem as finding the maximum spanning k-tree on the backbone graphs, where the backbone graphs are characterized by a linear sequence of the vertices. However, most of the traditional methods are not powerful to search through the huge conformation space. This implies a strong demand for more efficient models. We prove that the problem is W[1]-hard for the objective function defined on the cliques of the input graph. For solving the problem, we show that the problem can be solved in time O(k.(n)^{k+1}(k+1)^{k+2}) for every given k and we give evidence that our algorithm is very likely to be optimal.Our algorithm also works for different objective function defined over the cliques of the k-tree, which enables pertinent characterizations of real world problems.
dc.languageeng
dc.publisheruga
dc.rightspublic
dc.subjectRNA Structure Prediction, K-tree, Tree Decoposition, Dynamic Programming
dc.titleFinding optimal spanning k-trees in backbone graphs
dc.typeDissertation
dc.description.degreePhD
dc.description.departmentComputer Science
dc.description.majorComputer Science
dc.description.advisorLiming Cai
dc.description.committeeLiming Cai
dc.description.committeeRobert Robinson
dc.description.committeeRussell Malmberg


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