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dc.contributor.authorRoulo, Rebecca Marie
dc.date.accessioned2014-03-11T18:27:52Z
dc.date.available2014-03-11T18:27:52Z
dc.date.issued2013-08
dc.identifier.otherroulo_rebecca_m_201308_ms
dc.identifier.urihttp://purl.galileo.usg.edu/uga_etd/roulo_rebecca_m_201308_ms
dc.identifier.urihttp://hdl.handle.net/10724/29622
dc.description.abstractListeria monocytogenes is a foodborne pathogen than can cause spontaneous abortion and serious illness in neonates. Dose-response data on invasion and adverse pregnancy outcomes in Mongolian gerbils after oral challenge with L. monocytogenes were collected and compared to other animal models of listeriosis. Invasion of maternal organs occurred in dams exposed to ≥10^7 CFU L. monocytogenes, while fetal invasion occurred in dams exposed to ≥10^5 CFU. Fetal death occurred only in the highest dose group (10^9 CFU). Using fetal data, an ID50 of 2.60 × 10^6 CFU was calculated, while the LD50 was estimated to lie between 5 × 10^6 and 5 × 10^8 CFU. These results indicate that the gerbil is not more sensitive to L. monocytogenes invasion and adverse outcomes than some of the other animal models of listeriosis, namely the guinea pig and nonhuman primate.
dc.languageeng
dc.publisheruga
dc.rightspublic
dc.subjectListeria monocytogenes
dc.subjectpregnancy
dc.subjectMongolian gerbil
dc.subjectdose-response
dc.subjectanimal models
dc.titleThe Mongolian gerbil as a model for human listeriosis
dc.title.alternativean analysis and comparison of dose-response data
dc.typeThesis
dc.description.degreeMS
dc.description.departmentEnvironmental Health Science
dc.description.majorEnvironmental Health
dc.description.advisorMary Alice Smith
dc.description.committeeMary Alice Smith
dc.description.committeeFrederick Quinn
dc.description.committeeErin Lipp


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