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dc.contributor.authorZhang, Weijiang
dc.description.abstractThe pharmacokinetics and brain distribution of zidovudine (3’-azido-3’-deoxythymidine, AZT) and lamivudine ((-)- 2’, 3’-dideoxy-3’-thiacytidine, 3TC) were investigated in healthy cats.|Plasma concentrations of AZT declined rapidly with a terminal half- life of 1.4 ± 0.19, 1.4 ± 0.16 and 1.6 ± 0.26 hr following IV, IG and PO administration of 25 mg/kg AZT to six cats in a three way cross-over study. The area under the curve (AUC) following IV, IG, and PO administration was 64.7 ± 16.6, 42.5 ± 9.41 and 60.5 ± 17.0 mg´h/L, respectively|In a three way cross-over study, the half- lives of 3TC were 1.9 ± 0.21, 2.6 ± 0.66 and 2.7 ± 1.5 hr following IV, IG and PO administration of 25 mg/kg 3TC to six cats. The corresponding AUC was 130 ± 55.2, 115 ± 97.5 and 106 ± 94.9 mg´hr/L.|Both AZT and 3TC were well-absorbed following IG and PO administration.|To determine the distribution of AZT to cerebrospinal fluid (CSF) and brain, plasma, CSF, and brain samples were obtained from five cats that received a 7.0 mg/kg AZT loading dose, followed by three- hour infusion at 14.5 mg/kg/h. Mean (± STD) plasma, CSF, and brain concentrations of AZT at steady state were 26.3 ± 4.21, 8.27 ± 1.21, 6.37 ± 0.61 mg/L, respectively. In six cats, after 7.0 mg/kg loading dose of 3TC, followed by three-hour infusion at 5.5 mg/kg/hr, 3TC concentrations in plasma and CSF at steady states were 17.09 ± 5.26 and 1.73 ± 0.56 mg/L. No 3TC was detected in cat brain.|Pharmacokinetics of (-)-b-D-2,6-diaminopurine dioxolane (DAPD) and its metabolite, (-)-b-D-dioxolane guanosine (DXG) were estimated following administration of 50 mg/kg DAPD intravenously or orally to four adolescent ducks. Most DAPD concentrations were below the limit of quantitation. The AUC of DXG was 17.08 and 13.86 mg×hr/L following intravenous administration of DAPD and 18.26 and 23.11 mg×hr/L following oral administration. The half- life of DXG was 0.33 and 0.56 hr after intravenous DAPD and 0.85 and 0.86 hr following oral dosing of DAPD.
dc.languagePharmacokinetics of antiviral agents in veterinary medicine
dc.subjectFeline immunodeficiency virus (FIV)
dc.subjectLamivudine (L-2\',3\'-Dideoxy-3\'-thiacytidine
dc.subjectZidovudine (3\'-azido-3\'-deoxythymidine
dc.subjectDAPD ((-)-b-D-2,6-diaminopurine dioxolane)
dc.subjectDXG ((-)-b-D-dioxolane guanosine)
dc.titlePharmacokinetics of antiviral agents in veterinary medicine
dc.description.departmentPharmaceutical and Biomedical Sciences
dc.description.advisorF. Douglas Boudinot
dc.description.committeeF. Douglas Boudinot
dc.description.committeeMary Ann Stevenson
dc.description.committeeJames C. Price
dc.description.committeeD. Robert Lu
dc.description.committeeAnthony C. Capomacchia

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