System-based transcriptomic and metabolomic network analyses in Papaver somniferum
Kerry, John William
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Papaver somniferum is an annual plant which produces economically important medicinal alkaloids, oils, and seeds. The morphine biosynthesis pathway in P. somniferum has been characterized but a system-wide analysis of transcriptional modules that regulate the concentration of alkaloids within the plant has not yet been performed. In this study we use weighted gene co-expression network analysis (WGCNA) of a de novo assembly of 5 tissues of P. somniferum. We use differentially expressed transcripts to build a weighted gene co-expression network using the WGCNA bioconductor package. Finally we analyze those modules which correlate well with LC-MS/MS generated metabolite concentration values.