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dc.contributor.authorIbrahim, Muaz Alaaeldin
dc.date.accessioned2014-03-04T21:02:06Z
dc.date.available2014-03-04T21:02:06Z
dc.date.issued2013-05
dc.identifier.otheribrahim_muaz_a_201305_ms
dc.identifier.urihttp://purl.galileo.usg.edu/uga_etd/ibrahim_muaz_a_201305_ms
dc.identifier.urihttp://hdl.handle.net/10724/28770
dc.description.abstractA CD8 T cell based vaccine has been proposed as an alternative to the current influenza vaccine. The success of such a vaccine requires a better understanding of the overall CD8 T cell response in the respiratory tract and how it can be optimally generated and sustained. Previous work from our lab described a role for IL-15 in the migration of influenza-specific effector CD8 T cells (Teffs) to the lung airways. However, the mechanisms by which IL-15 mediates this migration is unclear. The research presented here shows that infected epithelial cells are a significant source of IL-15 mRNA. We also show that IL-15 deficiency affects chemokine and chemokine receptor expression on migrating Teffs. Gaining a greater understanding of the underlying mechanisms of IL-15 induced Teff migration will be an important step in the development of an optimal T cell mediated influenza vaccine.
dc.languageeng
dc.publisheruga
dc.rightspublic
dc.subjectInfluenza
dc.subjectCD8 T cells
dc.subjectMigration
dc.subjectChemokines
dc.subjectChemokine Receptors
dc.subjectIL-15
dc.titleThe role of chemokines and chemokine receptors in IL-15 mediated lymphocyte migration following influenza infection
dc.typeThesis
dc.description.degreeMS
dc.description.departmentCellular Biology
dc.description.majorCellular Biology
dc.description.advisorKim Klonowski
dc.description.committeeKim Klonowski
dc.description.committeeS. Mark Tompkins
dc.description.committeeRick Tarleton


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