The role of chemokines and chemokine receptors in IL-15 mediated lymphocyte migration following influenza infection
Ibrahim, Muaz Alaaeldin
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A CD8 T cell based vaccine has been proposed as an alternative to the current influenza vaccine. The success of such a vaccine requires a better understanding of the overall CD8 T cell response in the respiratory tract and how it can be optimally generated and sustained. Previous work from our lab described a role for IL-15 in the migration of influenza-specific effector CD8 T cells (Teffs) to the lung airways. However, the mechanisms by which IL-15 mediates this migration is unclear. The research presented here shows that infected epithelial cells are a significant source of IL-15 mRNA. We also show that IL-15 deficiency affects chemokine and chemokine receptor expression on migrating Teffs. Gaining a greater understanding of the underlying mechanisms of IL-15 induced Teff migration will be an important step in the development of an optimal T cell mediated influenza vaccine.