• Login
    View Item 
    •   Athenaeum Home
    • University of Georgia Theses and Dissertations
    • University of Georgia Theses and Dissertations
    • View Item
    •   Athenaeum Home
    • University of Georgia Theses and Dissertations
    • University of Georgia Theses and Dissertations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Metabolic engineering of Escherichia coli to produce plant specific secondary metabolites from aromatic amino acids

    Thumbnail
    Date
    2013-05
    Author
    Huang, Qin
    Metadata
    Show full item record
    Abstract
    Plants are known for producing diversified metabolites that are exclusively identified from plant sources. These plant-specific metabolites have been demonstrated to perform actively in signal transmission to assist plants growth under exogenous stress. This category of natural compounds attracts more attention beyond their roles in plants for their health promoting capabilities and medicinal potentials. However, commercialization of synthetic technology towards these therapeutic candidates is yet to be developed for their insufficient availability from native origins and uneconomical chemical approaches. In order to engineer more cost-effective alternatives of yielding these valuable metabolites, microbial production has been established by exploiting plant genes and enzymes to construct artificial synthetic pathway towards end products in categories of alkaloids, phenylpropanoids and isoprenoids. Caffeic acid, as a target compound in research, was produced in metabolically engineered E. coli. Highest titers from de novo production of caffeic acid and one-step conversion were achieved in this work.
    URI
    http://purl.galileo.usg.edu/uga_etd/huang_qin_201305_ms
    http://hdl.handle.net/10724/28766
    Collections
    • University of Georgia Theses and Dissertations

    About Athenaeum | Contact Us | Send Feedback
     

     

    Browse

    All of AthenaeumCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    About Athenaeum | Contact Us | Send Feedback