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dc.contributor.authorAbraham, Mathew
dc.date.accessioned2014-03-04T21:00:33Z
dc.date.available2014-03-04T21:00:33Z
dc.date.issued2013-05
dc.identifier.otherabraham_mathew_201305_ms
dc.identifier.urihttp://purl.galileo.usg.edu/uga_etd/abraham_mathew_201305_ms
dc.identifier.urihttp://hdl.handle.net/10724/28640
dc.description.abstractHistomonas meleagridis, a flagellated protozoan that causes histomoniasis or blackhead disease, is a great threat to the turkey industry with its heavy mortality and morbidity. In vivo studies using H. meleagridis isolated from 3 strains collected from outbreaks in North Carolina (Strain MNC), Michigan (Strain ZM) and Georgia (strain BG) and monocultures generated from the Buford isolate show that each isolate and monoculture varied in virulence. These results suggest the variation in the virulence may contribute to the severity of the blackhead outbreak. Currently, nitarsone (4-nitrophenylarsonic acid) is the only approved drug available in the United States for prevention of histomoniasis. Recent blackhead disease outbreaks in turkeys fed with nitarsone contained feed suggest the possibility of drug resistance in certain strains of the parasites. We tested the sensitivity of MNC, ZM and BG strains to nitarsone using both an in vitro cell culture model and in turkeys. These studies reveal that strain MNC has reduced sensitivity to the nitarsone.
dc.languageeng
dc.publisheruga
dc.rightspublic
dc.subjectHistomonas meleagridis
dc.subjectblackhead
dc.subjectvirulence
dc.subjectnitarsone
dc.titleBlackhead disease
dc.title.alternativevariation in the virulence of Histomonas meleagridis and its reduced sensitivity to nitarsone
dc.typeThesis
dc.description.degreeMS
dc.description.departmentPoultry Science
dc.description.majorPoultry Science
dc.description.advisorRobert Beckstead
dc.description.committeeRobert Beckstead
dc.description.committeeAndrew Moorhead
dc.description.committeeLarry McDougald


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