Whole genome sequences of Chlamydophila psittaci genotypes
Wolff, Bernard Jefferson
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Chlamydophila psittaci is an intracellular zoonotic pathogen responsible for large economic losses in the poultry industry and significant morbidity and mortality. This thesis contains the first whole genome sequences of four C. psittaci genotypes. The outer membrane and secretion system genes were specifically investigated because it is likely they contribute to invasion, survival, and virulence mechanisms. These were identified for each genome and compared with other fully sequenced members of the Chlamydiaceae family. While many of the type III secretion system genes found in other Chlamydiaceae genomes were present in C. psittaci, there was substantial sequence divergence. A number of the genes encoding predicted outer membrane proteins in the C. psittaci genomes were divergent or missing in several other species. These data may help explain the unique host preferences, tissue tropism, and unique virulence characteristics of C. psittaci compared to the other members of the Chlamydiaceae family.