Potential for enhancing biocompatibility through microstructuring and anti-coagulating biomolecular coatings
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To demonstrate the potential for increasing implantable sensor life span by sensor surface microstructuring, microwells were fabricated into SU-8(an epoxy based negative photoresist material). The microstructured surfaces were modified with heparinized medical grade polyurethane and the biocompatibility of the surfaces was evaluated with respect to protein adsorption and porcine platelet adhesion. With a commercial implantable sensor surface (MINIMED), as a control, the microstructured/ heparinized surfaces offered more resistance (p=0.05) to protein and cell attachment, suggesting potential for increasing implantable sensor lifespans through microstructuring.