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dc.contributor.authorRea, Adam Christopher
dc.date.accessioned2014-03-04T20:25:02Z
dc.date.available2014-03-04T20:25:02Z
dc.date.issued2011-12
dc.identifier.otherrea_adam_c_201112_ms
dc.identifier.urihttp://purl.galileo.usg.edu/uga_etd/rea_adam_c_201112_ms
dc.identifier.urihttp://hdl.handle.net/10724/27802
dc.description.abstractThe quinoline caging groups have potential for use in the release of bioactive molecules in vivo, and their two-photon sensitivity increases the potential spatial and temporal resolution of uncaging. Examining the photolyses of different 8-substituted quinolines in different solvent systems leads to a better understanding of the uncaging process of the quinoline caging groups. Additionally, described here is a series of quinoline-caged serotonins and capsaicinoids with sensitivity to 2PE for in vivo use in biological experiments. The reported compounds have by far the most favorable photochemical and photophysical properties for applications in cell biology and neurophysiology.
dc.languageeng
dc.publisheruga
dc.rightspublic
dc.subjectPhotoremovable protecting groups
dc.subjectCaged compounds
dc.subjectTwo-photon excitation
dc.subjectSerotonin
dc.subjectEpilepsy
dc.subjectZebrafish
dc.subjectCapsaicin
dc.subjectNociception
dc.subjectCalcium
dc.titleThe synthesis and characterization of a series of caged neurotransmitters with two-photon sensitivity for use in vivo
dc.typeThesis
dc.description.degreeMS
dc.description.departmentChemistry
dc.description.majorChemistry
dc.description.advisorTimothy Dore
dc.description.committeeTimothy Dore
dc.description.committeeVladimir V. Popik
dc.description.committeeGeorge Majetich


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