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dc.contributor.authorPrabhu, Rupal
dc.date.accessioned2014-03-04T20:24:56Z
dc.date.available2014-03-04T20:24:56Z
dc.date.issued2011-12
dc.identifier.otherprabhu_rupal_201112_ms
dc.identifier.urihttp://purl.galileo.usg.edu/uga_etd/prabhu_rupal_201112_ms
dc.identifier.urihttp://hdl.handle.net/10724/27793
dc.description.abstractAcrylic acid (CH2=CH-COOH) is a commodity chemical with an annual production of about four million tonnes. Thioester derivatives of acrylate are metabolic intermediates in organisms using the “acrylate pathway”. Megasphaera elsdenii and Clostridium propionicum metabolize lactate into propionate via the acrylate pathway by catabolizing lactate sequentially through lactyl-CoA, acrylyl-CoA, propionyl-CoA and propionate. The first and last reactions are catalyzed by a single CoA transferase, propionyl-CoA transferase. The goal of this study was to characterize these bacteria in the presence of acrylate. These organisms or the enzymes involved in acrylate metabolism could be important routes to industrial acrylate production.
dc.languageeng
dc.publisheruga
dc.rightspublic
dc.subjectMegasphaera elsdenii, Clostridium propionicum, acrylate, carbon balance, metabolic flux, steady-state, redox, metabolic pathway
dc.titleAcrylate metabolism in Megasphaera elsdenii
dc.typeThesis
dc.description.degreeMS
dc.description.departmentMicrobiology
dc.description.majorMicrobiology
dc.description.advisorMark Eiteman
dc.description.committeeMark Eiteman
dc.description.committeeWilliam Whitman
dc.description.committeeEric Stabb


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