Show simple item record

dc.contributor.authorEdwards, Jessica
dc.date.accessioned2014-03-04T20:24:00Z
dc.date.available2014-03-04T20:24:00Z
dc.date.issued2011-12
dc.identifier.otheredwards_jessica_201112_ms
dc.identifier.urihttp://purl.galileo.usg.edu/uga_etd/edwards_jessica_201112_ms
dc.identifier.urihttp://hdl.handle.net/10724/27710
dc.description.abstractTrypanosoma cruzi strains are genetically and biologically diverse. T. cruzi is divided into six discrete typing units which have specific geographical and ecological associations. In the United States (US), TcI and IV have been isolated from various hosts. Although human cases of Chagas’ disease are rare within the US, the prevalence of T. cruzi in sylvatic cycles is high. Experimental murine models closely mimic various aspects of Chagas’ disease, including immune mechanisms and histopathological implications of infection with different T. cruzi strains. Currently, little characterization work has been conducted on US strains. The goal of this thesis was to characterize the cytokine production of mice experimentally inoculated with diverse T. cruzi strains from the United States and South America and to determine changes in cytokine production and pathology in mice previously exposed to a US T. cruzi strain and subsequently challenged with a South American T. cruzi strain.
dc.languageeng
dc.publisheruga
dc.rightspublic
dc.subjectTrypanosoma cruzi
dc.subjectChagas’ disease
dc.subjectUnited States
dc.subjectwildlife
dc.subjectimmunology
dc.subjectcytokines
dc.subjectDTU’s
dc.subjectacute phase
dc.subjectchallenge study
dc.titleCharacterization of immunological responses in an experimental murine model to infection with distinct United States Trypanosoma cruzi isolates
dc.typeThesis
dc.description.degreeMS
dc.description.departmentVeterinary and Biomedical Sciences
dc.description.majorVeterinary and Biomedical Sciences
dc.description.advisorMichael Yabsley
dc.description.committeeMichael Yabsley
dc.description.committeeWendy Watford
dc.description.committeePeterson David


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record