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dc.contributor.authorBridgers, Joshua Seung Deok
dc.date.accessioned2014-03-04T20:01:53Z
dc.date.available2014-03-04T20:01:53Z
dc.date.issued2011-08
dc.identifier.otherbridgers_joshua_s_201108_ms
dc.identifier.urihttp://purl.galileo.usg.edu/uga_etd/bridgers_joshua_s_201108_ms
dc.identifier.urihttp://hdl.handle.net/10724/27398
dc.description.abstractSarcocystis neurona is an obligate intracellular parasite and the main agent behind equine protozoan myeloencephalitis a disease of critical importance to the equine industry. To facilitate the S. neurona genome project this study developed a bioinformatics framework that included assembly of the apicoplast genome, assembly and testing multiple transcriptome assembly algorithms and evaluating each to identify the superior assembly. Also, a pipeline for annotation of the nuclear genome was developed and its effectiveness was demonstrated via annotation of the S. neurona apicoplast genome. Finally, in order to facilitate study of and access to, the S. neurona genome, a database, SarcoDB, was created. It is intended that the results of this study will greatly aid in our understanding of the parasite, Sarcocystis neurona.
dc.languageeng
dc.publisheruga
dc.rightspublic
dc.subjectAnnotation
dc.subjectAssembly
dc.subjectApicoplast
dc.subjectDNA
dc.subjectEST
dc.subjectEimeria tenella
dc.subjectGenome
dc.subjectSarcocystis neurona
dc.subjectTranscriptome
dc.subjectToxoplasma gondii
dc.titleBuilding a framework
dc.title.alternativethe Sarcocystis neurona genome project
dc.typeThesis
dc.description.degreeMS
dc.description.departmentBioinformatics
dc.description.majorBioinformatics
dc.description.advisorJessica Kissinger
dc.description.committeeJessica Kissinger
dc.description.committeeBoris Striepen
dc.description.committeeAndrew Paterson


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