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dc.contributor.authorLane, Derrick Christopher
dc.date.accessioned2014-03-04T19:59:42Z
dc.date.available2014-03-04T19:59:42Z
dc.date.issued2011-05
dc.identifier.otherlane_derrick_c_201105_ms
dc.identifier.urihttp://purl.galileo.usg.edu/uga_etd/lane_derrick_c_201105_ms
dc.identifier.urihttp://hdl.handle.net/10724/27200
dc.description.abstractInsulators are elements that regulate genes through regulatory proteins and interactions with other insulators. A novel insulator discovered in Drosophila melanogaster, known as SF1, has been the primary focus of our lab. SF1 is located between two genes that are important for early embryogenesis, indicating that it may play a role in regulating these genes. In this study, we used a reverse genetic screen to identify any potential modifiers of SF1. We also investigated the interaction properties of SF1 with other elements in the Ftz-Antennapedia region. This study has led to the discovery of several candidate genes that have affected SF1 function. In addition, several novel elements exhibit cancellation with SF1. These latest findings have brought us closer to a better understanding behind the mechanisms responsible for the activity of SF1.
dc.languageeng
dc.publisheruga
dc.rightspublic
dc.subjectInsulator
dc.subjectin situ hybridization
dc.subjectembryo fixation
dc.subjectReverse genetic screen
dc.subjectRNAi
dc.titleIdentification of modifiers of the SF1 chromatin boundary
dc.typeThesis
dc.description.degreeMS
dc.description.departmentCellular Biology
dc.description.majorCellular Biology
dc.description.advisorHaini Cai
dc.description.committeeHaini Cai
dc.description.committeeKojo Mensa-Wilmot
dc.description.committeeJames D. Lauderdale


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