Identification of modifiers of the SF1 chromatin boundary
Lane, Derrick Christopher
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Insulators are elements that regulate genes through regulatory proteins and interactions with other insulators. A novel insulator discovered in Drosophila melanogaster, known as SF1, has been the primary focus of our lab. SF1 is located between two genes that are important for early embryogenesis, indicating that it may play a role in regulating these genes. In this study, we used a reverse genetic screen to identify any potential modifiers of SF1. We also investigated the interaction properties of SF1 with other elements in the Ftz-Antennapedia region. This study has led to the discovery of several candidate genes that have affected SF1 function. In addition, several novel elements exhibit cancellation with SF1. These latest findings have brought us closer to a better understanding behind the mechanisms responsible for the activity of SF1.