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dc.contributor.authorHaley, Jennifer Ayers
dc.date.accessioned2014-03-04T19:59:08Z
dc.date.available2014-03-04T19:59:08Z
dc.date.issued2011-05
dc.identifier.otherhaley_jennifer_a_201105_phd
dc.identifier.urihttp://purl.galileo.usg.edu/uga_etd/haley_jennifer_a_201105_phd
dc.identifier.urihttp://hdl.handle.net/10724/27148
dc.description.abstractPolymer-Peptide hybrids are a novel class of macromolecules that combine sophisticated functionality of biopolymers with synthetic versatility of synthetic polymers. Initially developed by biochemist for bio-medical applications, polymer-peptide hybrids have recently garnered a lot of attention by material scientists for a diverse range of applications including nanotechnology, photonics as well as traditional bio-medical applications. In this work, polymer-peptide hybrids were synthesized utilizing a modular grafting procedure in which Cysteine-containing peptides are “clicked” on the hydrophobic segment of the amphiphilic polymer polybutadiene-block-poly(ethylene oxide) (PBD-b-PEO) via free radical addition of the thiol onto the double bonds. These polymer-peptide hybrids were then applied in two areas of research: tuning amphiphilic block copolymer self-assemblies with grafted charged peptides and combinative self-assembly with DNA. Grafting short charged peptides onto PBD-b-PEO results in self-assemblies driven by a combination of hydrophobic association, ionic disturbances and H-bonding. Clustering gene-binding peptides, KWKn, onto (PBD-b-PEO) dramatically changes the DNA condensation pathway. By varying the grafting density and peptide sequence, precise control over the DNA condensation process can be accomplished.
dc.languageeng
dc.publisheruga
dc.rightspublic
dc.subjectPolymer-Peptide Hybrids
dc.subjectSelf-assembly
dc.subjectPolyion Complexes
dc.subjectDNA Condensation
dc.titlePolymer-peptide hybrids
dc.title.alternativeself-assembly and combinative assembly with DNA
dc.typeDissertation
dc.description.degreePhD
dc.description.departmentChemistry
dc.description.majorChemistry
dc.description.advisorYan Geng
dc.description.committeeYan Geng
dc.description.committeeVladimir V. Popik
dc.description.committeeGeert Jan Boons


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