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dc.contributor.authorArte, Ankit Arvind
dc.date.accessioned2014-03-04T19:57:48Z
dc.date.available2014-03-04T19:57:48Z
dc.date.issued2011-05
dc.identifier.otherarte_ankit_a_201105_ms
dc.identifier.urihttp://purl.galileo.usg.edu/uga_etd/arte_ankit_a_201105_ms
dc.identifier.urihttp://hdl.handle.net/10724/27046
dc.description.abstractHistone modifications, especially methylations, play a vital role in transcriptional activation of genes within a human body. Hence, we created a web service to help users to study the local spatial structure of these modifications along a chromosome along with their patterns. We created four queries for this purpose. A memory mapping technique along with binary search was used to help obtain quick output results of these queries. We also created a tree representation to view the homogenous regions of these modifications as we walk through the chromosome. We not only show there is a large non-uniformity of the spatial distribution of epigenetic marks in these regions, but also that there are a large number of regions which are locally multinomial.
dc.languageeng
dc.publisheruga
dc.rightspublic
dc.subjectHigh-Speed queries, Epigenetic code, Human genome, Histone modifications, Homogenous regions within a chromosome
dc.titleHiDEW
dc.title.alternativehigh-speed determination of epigenetic code rendered through a Web application
dc.typeThesis
dc.description.degreeMS
dc.description.departmentComputer Science
dc.description.majorComputer Science
dc.description.advisorJonathan Arnold
dc.description.committeeJonathan Arnold
dc.description.committeeKrzysztof Kochut
dc.description.committeeE. Rodney Canfield


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