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dc.contributor.authorTrau, Heidi Anne
dc.date.accessioned2014-03-04T19:00:29Z
dc.date.available2014-03-04T19:00:29Z
dc.date.issued2010-12
dc.identifier.othertrau_heidi-anne_201012_ms
dc.identifier.urihttp://purl.galileo.usg.edu/uga_etd/trau_heidi-anne_201012_ms
dc.identifier.urihttp://hdl.handle.net/10724/27023
dc.description.abstractHoxa3 is required for the development of the third and fourth pharyngeal pouch-derived organs, formation of the cartilages of the throat and the hyoid bone, formation of the ninth and tenth cranial nerves, and in development of the soft palate. To determine when Hoxa3 is required in the formation of each of these structures, I used a globally expressed inducible Cre recombinase to temporally knock out Hoxa3 during development. To determine the role of Hoxa3 within the neural crest and endoderm, the two tissue types that give rise to all of the organs and structures affected in the Hoxa3 null mouse, as well as the parathyroid and thymus, I used tissue-specific Cre recombinases to knock out Hoxa3. Together, these experiments give us a good indication of when Hoxa3 function becomes necessary in the formation of the various pharyngeal structures, and of the role it plays in each.
dc.languageeng
dc.publisheruga
dc.rightspublic
dc.subjectHoxa3
dc.subjectNeural crest
dc.subjectEndoderm
dc.subjectThymus
dc.subjectParathyroid
dc.subjectThyroid
dc.subjectHyoid
dc.subjectCranial nerve
dc.subjectSoft palate
dc.subjectCre recombinase
dc.subjectTemporal-global
dc.subjectTissue-specific
dc.titleUnderstanding the role of Hoxa3 in pharyngeal development
dc.title.alternativetissue-specific and temporal-global deletions
dc.typeThesis
dc.description.degreeMS
dc.description.departmentGenetics
dc.description.majorGenetics
dc.description.advisorNancy R. Manley
dc.description.committeeNancy R. Manley
dc.description.committeeJames D. Lauderdale
dc.description.committeeBrian Condie


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