Show simple item record

dc.contributor.authorGrove, Jeremy Lee
dc.date.accessioned2014-03-04T18:59:07Z
dc.date.available2014-03-04T18:59:07Z
dc.date.issued2010-12
dc.identifier.othergrove_jeremy_l_201012_phd
dc.identifier.urihttp://purl.galileo.usg.edu/uga_etd/grove_jeremy_l_201012_phd
dc.identifier.urihttp://hdl.handle.net/10724/26903
dc.description.abstractChapter I: The first asymmetric total syntheses of (+)-19-deoxyicetexone, (–)-icetexone, and (+)-5-epi-icetexone was achieved. This study featured: (1) an enzymatic resolution strategy to construct an asymmetric A-ring; (2) an efficient six step synthesis of the C-ring; (3) the development of a novel Friedel–Crafts cyclialkylation reaction to forge a 6-7-6 cycloheptatriene nucleus. Additionally, our efforts have resulted in a reassignment of the physical data of two epimeric icetexones. Chapter II: A short synthetic route for the preparation of functionalized 8- and 6-hydroxyisochromenes has been developed. Both strategies feature novel intramolecular hydroalkoxylations of conjugated alkynes. Additionally, a novel one-pot oxidation-cyclization-aromatization of a cyclohexadienone-alcohol has resulted in a new method for preparation of functionalized 8-hydroxyisocoumarins.
dc.languageeng
dc.publisheruga
dc.rightspublic
dc.subjecticetexane, icetexone, deoxyicetexone, 5-epi-icetexone, triterpene, total synthesis, Friedel–Crafts, isochromene, isocoumarin, heterocycle
dc.titleChapter i: asymmetric total syntheses of (+)-19-deoxyicetexone, (–)-icetexone, and (+)-5-epi-icetexone chapter ii: a practical synthesis of functionalized 6- and 8-hydroxyisochromenes and isocoumarins and a novel route to 8-hydroxyisocoumarins
dc.typeDissertation
dc.description.degreePhD
dc.description.departmentChemistry
dc.description.majorChemistry
dc.description.advisorGeorge Majetich
dc.description.committeeGeorge Majetich
dc.description.committeeRobert Phillips
dc.description.committeeGeert Jan Boons


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record